该短语是主谓结构，需根据主语调整物主代词（one's = my/your/his/her/our/their等），常用时态为一般现在时（描述当前状态）或现在进行时（强调"正在逐渐崩溃"的过程）。
She lost her mind after her only child died in the accident.
（她唯一的孩子在事故中去世后，她精神失常了。）
The old man started losing his mind after years of loneliness.
（老人因多年孤独开始变得神志不清。）
I'm losing my mind waiting for the exam results—they're taking forever!
（等考试结果我快疯了——怎么这么久！）
Don't ask me to fix this computer again—I'm losing my mind with all these technical problems!
（别再让我修这台电脑了——这些技术问题快把我搞疯了！）
How did you not lose your mind when they canceled your flight at midnight?
（他们半夜取消你的航班时，你怎么没崩溃？）
She managed not to lose her mind even during the most stressful weeks at work.
（即使在工作压力最大的几周里，她也努力保持了理智。）
语境区分：正式场合（如医学/法律文本）更常用"go insane"或"become mentally ill"；"lose one's mind"更偏向口语化，用于日常对话或非正式写作。
同义替换：口语中还可表达为"lose one's marbles"（更诙谐，如："He's lost his marbles if he thinks that plan will work!" 他要是觉得那计划能行，简直是疯了！）。
简言之，"lose one's mind"是表达"情绪/精神失控"的常用短语，核心是"无法承受某种压力或状态"，具体含义需结合语境判断。