“使惨败”可以翻译为 “cause a crushing/humiliating/disastrous defeat (to someone/something)” 或者 “lead to a crushing/humiliating/disastrous failure (for someone/something)”。
Crushing defeat：强调失败的程度非常严重，令人无法承受。
Humiliating defeat：侧重于失败带来的羞辱感。
Disastrous failure：突出失败的灾难性后果。
根据具体语境，可选择合适的表达。例如：
Their poor strategy caused a crushing defeat for the team.（他们糟糕的策略让球队惨败。）
His overconfidence led to a humiliating failure in the competition.（他的过度自信导致他在比赛中惨败。）