"对这个问题" can be translated into English as "regarding this issue", "with regard to this question", "as for this problem", or "in relation to this matter", depending on the context and the level of formality required.
For example:
Regarding this issue, we need to conduct further research. （对这个问题，我们需要进行进一步的研究。）
With regard to this question, I have a different opinion. （对这个问题，我有不同的看法。）