“苦心经营”常见的英文表达有 “work painstakingly to manage/run” 、“put a lot of effort into managing/operating” 或 “run with great pains” 等，具体使用可根据语境灵活调整。以下是一些例句：
1、 He worked painstakingly to manage the small business for years before it finally became profitable.
（他苦心经营这家小企业多年，终于让它实现了盈利。）
2、 The team put a lot of effort into operating the project, and it eventually turned out to be a great success.
（团队苦心经营这个项目，最终取得了巨大的成功。）
3、 She ran the restaurant with great pains, turning it from a small eatery into a renowned local brand.
（她苦心经营这家餐馆，将它从一家小饭馆发展成了当地知名的品牌。）