“精明地处理”可以翻译为 "handle/deal with something shrewdly/wisely" 或 "manage something skillfully and prudently"。
具体用法可根据语境调整：
Handle shrewdly（精明应对）：强调策略性和敏锐判断
Deal with wisely（明智处理）：突出决策的合理性
Manage skillfully and prudently（精明且谨慎地管理）：适用于复杂事务的统筹
例句：
She handled the negotiations shrewdly, securing a better deal for her company.（她精明地处理了谈判，为公司争取到了更有利的条件。）
The CEO deals with crises wisely, turning potential disasters into opportunities.（这位CEO明智地应对危机，将潜在灾难转化为机遇。）
根据语境选择最贴切的短语即可。