"使密封于管内" can be translated as "to seal (it) inside the tube" or "to keep (it) sealed within the tube".
Here are a few example sentences to illustrate the usage:
1、 We need to make sure the substance is sealed inside the tube to prevent any leakage.
(我们需要确保物质被密封在管内,以防止任何泄漏。)
2、 The experiment requires us to keep the sample sealed within the tube during the entire process.
(实验要求我们在整个过程中将样品密封在管内。)