“使显著”常见的英文表达有“make significant”“render significant” 或 “lead to a significant（change/effect等，根据具体语境补充完整） ”。具体使用示例如下：
make significant：This new policy is expected to make significant improvements in the local economy.（预计这项新政策将使当地经济有显著改善 。）
render significant：The new discovery renders the previous theory significant in a new context.（这一新发现使得先前的理论在新情境下有了显著意义。 ）
lead to a significant...：The investment in education is likely to lead to a significant increase in the quality of the workforce.（对教育的投资很可能会使劳动力质量有显著提高。 ）