"计算机指令系统" can be translated into English as "computer instruction set" or "instruction set architecture (ISA)".
"Computer instruction set" is a more straightforward and general term, referring to the collection of instructions that a computer's processor can execute.
"Instruction set architecture (ISA)" is a more technical and specific term, often used in computer science and engineering contexts. It defines the set of instructions that a processor can understand and execute, as well as the format and meaning of those instructions.
Both translations are acceptable, depending on the context and level of technicality required.