"用程序指令" can be translated as "using program instructions" or "with program instructions" in English, depending on the context.
If you're emphasizing the action of utilizing program instructions, you might say "using program instructions."
If you're describing a situation or method that involves program instructions, you could say "with program instructions."
For example:
"We can automate this task using program instructions."（我们可以用程序指令来自动化这个任务。）
"The system operates efficiently with program instructions."（系统通过程序指令高效运行。）